According to a new article published in the journal PLOS Medicine, there is a cluster of seven symptoms that together can be used to maximize COVID-19 detection. Performing this detection as quickly as possible is key to ensuring effective transmission line control, especially when the ability to perform diagnostic tests is limited.
In the new study, scientists obtained throat and nose swabs with valid PCR test results for SARS-CoV-2 from more than one million volunteers in England over the age of 5. The data was collected during eight rounds of testing conducted from June 2020 to January 2021 as part of the REACT-1 Community Broadcast Time Assessment (REACT-1). In addition, the participants were asked about the symptoms they experienced the week before the test .
The model was developed in rounds 2-7, with these seven symptoms selected as predictors of a positive PCR result: loss or change in smell, loss or change in taste, fever, persistent cough, chills, loss of appetite, and pain. muscular. Of the seven, only the first four are being considered in the UK to assess the efficacy of PCR. In the eighth round of the trial, the resulting model showed that using 7 identified symptoms to prescribe a CRP test would result in between 30% and 40% of symptomatic individuals in England being eligible for the test (compared with the current 10%) and, if all eligible were screened, this would result in between 70% and 75% of positive cases .
"To improve the detection rates of positive PCR and, therefore, improve the control of virus transmission through isolation measures, we propose to expand the list of symptoms used for classification to the 7 symptoms that we have identified", say the authors .
"These results suggest that many people with COVID-19 will not be tested and therefore will not be isolated because their symptoms do not match those used in current public health guidelines to identify infected people," he adds. Paul Elliott., Imperial Researcher. College London, UK “We understand that clear criteria are needed for testing and inclusion of many of the symptoms commonly found in other illnesses such as the flu. Seasonal conditions can put people at risk of unnecessary isolation. I hope our more informative symptom findings mean that the testing program can use the available evidence to help optimize the detection of infected people . "
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